Thyroid Care – Treatment, Care and Future Trends

divyar87 Jul 21, 2019
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How are the Different Kinds of Thyroid Problems Treated?

https://www.youtube.com/watch?v=jl65GULkC0I

Image result for future treatment of hyperthyroidism 2019

The main goal of treatment for any thyroid issue is to restore normal blood levels of thyroxine hormone. While Hypothyroidism is treated by compensating the under produced thyroid hormone, hyperthyroidism is treated by preventing your thyroid gland from overproducing the hormone.

Specific treatments are as follows:

For Hyperthyroidism:

  1. Antithyroid drugs (methimazole, propylthiouracil, and carbimazole)
  2. Radioactive iodine treatment
  3. Surgical removal of thyroid- thyroidectomy
  4. Beta-blockers to treat hyperthyroidism symptoms

Hypothyroidism treatment

  1. Thyroid hormone replacement drugs (levothyroxine)
  2. A synthetic form of T3 hormone (liothyronine)
  3. Hormone replacement drugs (Natural desiccated thyroid)

Treatment for Hashimoto's disease:

  1. Drug low dose naltrexone (LDN)

Treatment for Hashimoto's thyroiditis:

  1. Thyroid hormone replacement drugs

Goiter treatment:

  1. thyroid hormone replacement drugs
  2. Radioactive iodine

Upcoming Trends in Management & Care for Thyroid Problems

Cabozantinib Shows Promise as First-Line Treatment for Refractory Differentiated Thyroid Cancer 

A kinase inhibitor called cabozantinib could be a viable therapy option for patients with metastatic, radioactive iodine-resistant thyroid cancer. In a trial initiated and led by the Abramson Cancer Center and the Perelman School of Medicine at the University of Pennsylvania, tumors shrunk in 34 out of 35 patients who took the drug, and more than half of those patients saw the tumor size decrease by more than 30 percent.

Potential therapy for treatment-resistant hypothyroidism proves effective in lab study

A new "metal-coordinated" drug-delivery technology potentially could be used to supplement the standard therapy for hypothyroidism, which affects nearly 10 million Americans, and many more patients worldwide, according to results of a study conducted by the Researchers at Rush University Medical Center. They have been pursuing an improved treatment for the minority of hypothyroid patients who don't respond well to the standard therapy. Now, their investigations into the way thyroid hormones are given in tablets are absorbed and metabolized by the body suggest that a metal-coordinated molecule could prove to be a more effective therapy for all hypothyroid patients, according to Dr. Antonio Bianco. He is a professor of medicine at the University of Chicago who was formerly a researcher and clinician at Rush, where the work detailed in the Thyroid paper was completed.

Nonthionamide Drugs for the Treatment of Hyperthyroidism

Nonthionamide Drugs (NTADs) can be used to control symptoms of hyperthyroidism in some circumstances in which thionamide cannot be used or in combination with drug regimens. The mechanisms of action, indications, and side effects of NTADs are different. Understanding those differences can help the clinician select the appropriate drugs for the patients. Novel medications for GD such as rituximab, SMLs, and MAbs with TSHR antagonist effect are still being investigated

Future treatment for hypothyroidism:

l-Thyroxine monotherapy for athyreotic rats results in a high T4:T3 ratio at doses sufficient to normalize serum TSH levels. Yet, the brain, liver, and skeletal muscle tissues of these l-thyroxine–treated animals continue to exhibit markers of hypothyroidism, probably because of the inability of l-thyroxine monotherapy to restore tissue levels of T3. Only combination therapy with l-thyroxine plus l-triiodothyronine normalized all thyroid hormone–dependent measures, including serum and tissue T3 levels. Whether tissue-specific markers of hypothyroidism are restored with l-thyroxine monotherapy in humans remains to be determined, as does the ability of l-thyroxine plus l-triiodothyronine combination therapy to normalize the serum T4:T3 ratio without adverse events. The development of a novel drug delivery system for l-triiodothyronine would facilitate these studies. In humans, a factor associated with response to combination therapy in a large clinical trial is the Thr92Ala polymorphism in the type 2 deiodinase gene (DIO2), wherein the sub-population of patients with this genetic alteration had improved well-being and preference for combination therapy. This has led investigators to consider whether this polymorphism could confer a defect in the D2 pathway, but normal Thr92AlaD2 enzyme kinetics have been demonstrated. Only recently has the Thr92AlaD2 protein been found to have a longer half-life, ectopically localize in the Golgi apparatus, and significantly alter the genetic fingerprint in cultured cells and in the temporal pole of the human brain without evidence of reduced thyroid hormone signaling. If hypothyroid carriers of Thr92AlaD2 benefit from alternate therapeutic strategies in replicate studies, then personalized medicine—based on genotype— may have a role.

 
References
https://www.healthdirect.gov.au/causes-of-thyroid-problems
https://www.webmd.com/women/guide/understanding-thyroid-problems-basics#1
https://www.womenshealth.gov/a-z-topics/thyroid-diseasehttps://medlineplus.gov/thyroiddiseases.html
https://www.mayoclinic.org/diseases-conditions/hypothyroidism/symptoms-causes/syc-20350284
https://www.medicinenet.com/hyperthyroidism/article.htm
https://my.clevelandclinic.org/health/diseases/8541-thyroid-disease/management-and-treatment
https://www.verywellhealth.com/thyroid-disease-treatment-4014309
https://www.pennmedicine.org/updates/blogs/penn-physician-blog/2018/february/cabozantinib-shows-promise-as-first-line-treatment-for-refractory-differentiated-thyroid-cancer
https://www.rush.edu/news/press-releases/potential-therapy-treatment-resistant-hypothyroidism-proves-effective-lab-study
https://www.hindawi.com/journals/ije/2018/5794054/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980994/

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sven massina Jun 10th, 2020
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Rebecca Dunn May 5th, 2020
I've been looking for this kind of article is great and let me help someone.
Maira Apr 12th, 2020
Asking questions are actually nice thing if you are not understanding anything entirely, but this piece of writing provides nice understanding even.
divya Feb 18th, 2020
the above post is really informative and appreciable for the people who are suffering from thyroid. one of my neighbors also suffered from thyroid as Thyroid hormones act throughout the body, influencing metabolism, growth, and development, and body temperature. so he was facing all types of symptoms of thyroid disease and took treatment by the different good doctors but didn't get relief so he moved forward to Ayurveda. Ayurvedic treatment which helped him to overcome or stop the disease of the thyroid.
Main Moderator Nov 16th, 2019
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yash Nov 16th, 2019
Thank you for sharing this! I would like to say, In Ayurveda, there is a cure for thyroid that is done with the help of ayurvedic therapy. It is known as Jain's cow urine therapy. It uses a holistic approach of Panchgavya for treating many chronic diseases. I think people who got tired of modern treatments should also opt for this therapy.
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Rahul Oct 23rd, 2019
I appreciate your efforts, you are really good. I must say that this post is really informative and helpful. Thanks and keep sharing your knowledge with us.
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Dear Reader – Thank you for your feedback.
Main Moderator Aug 9th, 2019
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